The 7.6 magnitude tremor struck east of Ometepec, near the Pacific Coast resort of Acapulco.
Lasting several minutes, it shook buildings some 400 kilometres away in Mexico City, sending office workers rushing out onto the streets. Mobile phone networks have been affected and traffic was snarled in the capital.
Mexican President Felipe Calderon said on his twitter account that there were no reports of serious damage. Local media says at least one person in the capital has been injured by the collapse of a bridge.
A strong 7.4-magnitude earthquake hit central and southern Mexico on Tuesday, damaging some 800 homes near the epicenter and swaying tall buildings and spreading fear and panic hundreds of miles away in the capital of Mexico City. (March 20)